Now the fight begins.

The Senate voted on party lines Saturday night to end a Republican filibuster and bring a bill that would overhaul the nation’s health-care system to the Senate floor.

After days of indecision, the two final holdouts — Sens. Blanche Lincoln (D-Ark.) and Mary Landrieu (D-La.) — voted with all 60 members of their caucus to support a procedural motion to begin debate. Though strictly parliamentary, the vote marks a milestone in the quest for health-care reform reignited by President Obama’s election.

The vote set up weeks of debate. Senate Majority Leader Harry M. Reid (D-Nev.) is aiming for final passage before Christmas.

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